青年胃癌53例临床病理特征与预后分析中国肿瘤临床.PDFVIP

2011年第38 卷第2 期 中国肿瘤临床 97 青年胃癌53例临床病理特征与预后分析 ① 邢艳敏 谢广茹 潘战宇 孙海燕 刘东颖 分析青年胃癌患者的临床病理特征，探讨影响预后的因素。 回顾性分析天津医科大学附属肿瘤医院 摘要 目的： 方法： 2000 年1 月～2006 年12 月间行胃癌手术治疗的年龄≤35 岁的青年患者53 例的临床资料。 青年人胃癌临床表现以上腹部 结果： ： 疼痛不适最常见，占77.4% ，男女之比为1 1.65 ，肿瘤部位以胃窦部常见。病理分类弥漫型癌占81.1% ，TNM 分期Ⅲ～Ⅳ期病例占 83% ；84.9%原发灶穿透浆膜（T ）；77.4% 患者伴淋巴结转移（N ）；32.1%伴有远处转移（M ）。全组根治手术率64.2% 。术后l、3 3-4 1-3 1 和5 年生存率分别为54.7 ％、22.6 ％和18.3 ％。多因素分析显示：TNM 分期、手术性质、术后辅助化疗是影响预后的独立因素。结 青年胃癌以女性和弥漫型癌所占比例较高，临床分期晚，根治性手术切除率低。TNM 分期、手术性质及术后辅助化疗是评价 论： 其预后的重要参考因素。 关键词 胃肿瘤 青年 临床病理特征 预后 doi:10.3969/j.issn. 1000-8179.2011.02.010 Clinicopathologic Features and Prognosis of Gastric Cancer in 53 Young Adults Yanmin XING, Guangru XIE, Zhanyu PAN, Haiyan SUN, Dongying LIU Correspondence to: Guangru XIE, E-mail: xieguangru@126.com Department of Integrative Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Abstract Objective: To analyze the clinicopathologic features and the prognostic factors of gastric cancer in young adults. Methods: A retrospective study was peiformed using the clinical data of 53 patients aged 35 years or younger with all stages of gastric cancer who underwent surgery in our hospital between 2000 to 2006. Results: Of the 53 cases, the median age was 33 years (range: 25 ～35 years), and the most common symptoms were abdominal pain and discomfort, reported by 77.4 %. The ratio of male to female was 1:1.65, and tumors were mostly found in the gastric antru