探讨帕金森病抑郁的发生率及相关因素.docVIP

探讨帕金森病抑郁的发生率及相关因素 勃利县青山乡卫牛院154531 目的研究分析帕金森病患者伴发抑郁的发牛率及相关因素。方法: 此次研究的对象是选取笔者所在科室2012年9月?2015年9月收治的136例帕 金森患者。将其临床资料进行回顾性分析，并作为观察组，并筛选同期神经科普 通患者136例为对照组。釆用统一的帕金森病评定量表(UPDRS)、汉密尔顿抑 郁量表(HAMD?24项版木)等进行测查，并比较帕金森病抑郁的发牛率。结果 观察组发牛抑郁98例，抑郁率为72.05%,对照组出现抑郁8例，抑郁率为5.88%, 差异有统计学意义(Plt;0.05)o帕金森病抑郁发牛率与年龄、性别、文化程度 无相关性，而与病程、病情程度相关，病程越长，UPDRS评分和Hoehn-Yahr分 型越高，抑郁的发牛率就越高。结论帕金森患者中抑郁的发牛率极高，其与帕 金森患者病程和症状严重程度密切相关，病程长者发牛率越高。 关键词帕金森病；抑郁；发生率；相关因素 [Abstract]Objective To study the incidenee and related factors of depression in patients with Parkinsorfs disease.Methods the object of this study is to select the authors departme nt from September 2012 to September, 136 cases of Parkins on patie nts were treated.The clinical data were retrospectively an a lyzed, and the control group were selected as the observation group, and 136 cases of the same period were selected as the control group.Usi ng the un 讦 ied Parki nsons Disease Rati ng Scale (UPDRS), Hamilton Depression Scale (HAMD-24 version) and other survey, and compare the incidenee of depression in Parkinsons disease.Results in the observation group, 98 cases of depression, the rate of depression was 72.05%, the control group appeared 8 cases of depression, the depression rate was 5.88%, the differenee was statistically significant (Plt;0.05 ) .There was no correlation between the in cide nee of depression and age, sex and education in Parkins ons disease, but with the course of disease, the degree of disease, the I on ger the course, the higher the UPDRS score and HoehYahr score, the higher the incidenee of depression.Conclusion the incidenee of depression in patients with Parkinson is very high, which is closely related to the course of disease and the severity of the symptoms of Parkinson. [Key words]Parkinsons disease； depression； incidenee； related factors 帕金森病(parkinson disease, PD)是一种影响患者活动能力的中枢神经系 统慢性疾病，是中老年人常见的神经系统变性疾病，65岁以上人群患病率为 1000/10万，随年龄增高，男性稍多于女性[1-3]o帕金森早期主要表现为静止性 震颤、肌强直、行动缓慢、动作起动困难和姿势异常等，还常伴有抑郁、焦虑、 肢体酸痛不适、便秘、多汗、流涎等症状[4-6]