油漆和染发剂导致人体染色体畸变的分析院附2例首报染色体.PDF

2010;30(7) 南方医科大学学报(JSouthMedUniv) 窑1651窑 油漆和染发剂导致人体染色体畸变的分析院附2例首报染色体核型 1 2 2 2 1 2 谢 军 袁刘彦慧 袁黎丽芬 袁吴亚敏 ( 开封市中医院检验科袁河南 开封475001曰 中山大学附属东华医院医学遗 传实验室袁广东 东莞 523110) 摘要院目的 分析一对夫妻长期从事油漆或染发职业对早期胚胎细胞染色体突变的作用袁为预防不良妊娠和遗传缺陷 儿出生积累临床资料遥方法 通过1例新生儿和1例妊娠21周胎儿染色体突变的临床和实验检测以及其父母双方血液 相关指标的分析袁探讨育龄期长期接触油漆或染发剂对早期胚胎细胞基因突变的影响遥 结果 1例新生儿和 1例胎儿 染色体均发生突变袁核型分别是46,XX,del(2)(pterq31) 和46袁XX,t(4;12;15)袁2例的父母亲染色体正常袁但因长期接触油 漆或染发剂而有头晕尧头疼尧失眠等症状袁淋巴细胞微核发生率和血铅浓度均显著升高袁并有白细胞尧血小板和血红蛋白 下降等遥 结论 长期从事油漆或染发工作可引起机体中毒袁母体中的有害物质通过胎盘而影响早期胚胎正常发育袁最终 可导致胚胎基因损伤和染色体突变袁因此计划妊娠前后要注意脱离有害环境袁或通过相关检查了解机体中毒状况袁以减 少不良妊娠的发生遥 关键 院染色体突变曰油漆曰染发剂 中图分类号院R956 文献标识码院A 文章编号院1673-4254渊2010冤07-1651-03 Aclinicalanalysisoffetalchromosomalaberrationinducedbypaintandhairdye 1 2 2 2 XIEJun ,LIUYan-hui,LILi-fen,WUYa-min 1 2 ClinicalLab,ChineseTraditionalHospitalofKaifengcity,Kaifeng475001,China; DepartmentofMedicalGenetics,TungWahHospital ofSunYat-senUniversity,Dongguan523110,China Abstract: Objective Toanalyzetheeffectoflong-termexposuretopaint orhairdyeonchromosomalaberrationofearly embryos. Methods We analyzed 2 cases of fetal or infantile chromosome aberration in which the parents experienced long-termexposuretopaintandhairdye. Result Thechromosomalmutationsweredetectedinone3-month-oldinfantand one21-week-oldfetus, andthekaryotypeswere 46,XX,del(2)(pterq31)and46袁XX,t(4;12;15), respectively. Theirparents workedwithlong-termexposuretopaintandhairdyeanddevelopedsuchsymptomsasdizziness, headache, andinsomnia. The chromosomes of the parents remained normal, but the micronuclei of the lymphocytes and plasma lead level were increasedwithdecreasedWBC, platelet, andHGB. Conclusion Longexposuretopaintorhairdyecancausepoisonand affectthenormalgr