碳杂重键加成反应.pptVIP

完成下列反应： 比较有光学活性的下列两个化合物，用　Ｈ２１８Ｏ在酸催化下水解的反应产物，用反应机制加以说明。 5.3 Addition to C,O multiple bonds Base catalyzed Step 1. Step 2. Mechanism No matter which species attack first, the rate-determining step is usually the one involving Nu attack! Acid catalyzed Step 1. Step 2. Competed procedure: Substitution Step 3. Step 4. Step 2. Step 1. When A, B are H, R, Ar, the substrate is an aldehyde or ketone, these almost undergo addition! For carboxylic acids and their derivatives (B = OH, OR, NH2, X, etc), the substitution is major procedure! Activity Electronic effect CCl3-CH=O + HOH CCl3-CH(OH)2