合理利用小鼠动物模型研究基因调节与病理发育.pptVIP

Mouse Model for Gene Regulation Studies Course Materials Introduction to Gene Regulations Introduction to mouse models Introduction to transgenic techniques Examples: VEGF gene regulation and pathologic development Transgenic Technology Part 1： Basis of classic transgenics Part 2： Gene Targeting Part 3： Applications What’s transgenic？ Narrow Definition：Artifacial insertion of DNA fragment into genome Broad Definition：Artifacial modification of genome, including insertion, mutation and deletion Importance of Transgenic Technology Basic Research Gene regulation，promoter function Gene expr