威尔森氏病病患服用锌醋酸盐胶囊应注意事项.doc

2007威爾森氏病病友聯誼會秋季聯誼活動 資料提供: 威爾森氏病病患服用鋅醋酸鹽膠囊應注意事項 【與金屬螯合劑併用時】： 鋅與其他藥物(ascorbic acid、penicillamine、trientine)並無顯示會有交錯反應，(交錯反應是指二者藥物一起用於長期治療,並不會互相抑制或影響療效)，一般而言，服用其他藥物同時服用鋅醋酸鹽並不需特別注意，但如果您目前是與金屬螯合劑併用治療時，請特別注意服用藥物的時間,兩者必須間隔至少一個小時。以避免同時服用,鋅也被金屬螯合劑螯合掉,而因此減低鋅的效用。 【與食物併用時】： 鋅醋酸鹽膠囊的服用應為空腹使用，至少飯前一小時或飯後二到三小時，若有腸胃不適的副作用，通常為早上空腹那ㄧ次，則建議可改成早餐與中餐之間服用，若還是無法改善，或許可以與一些含有蛋白質的食物併用(請選擇較不會影響鋅的吸收之蛋白質食物)。有副作用狀況，請勿自行減藥或停藥，請與您的醫師聯絡。 以下整理會影響鋅吸收的食物相關文獻資料: 以口服方式給予zinc sulfate(含有25mg的元素鋅)，分成兩個組別：一組是同時給予鋅鹽與單一種類食物，另一組是單獨給予鋅鹽，並在同一個受試者身上測試這兩種情況的差異，比較不同種類的食物對於血中鋅濃度的影響，結果顯示麵包、蔬菜、水果、蛋、飲料如牛奶、咖啡等食物會降低血中鋅的濃度。 各種不同食物對於同一受試者身上對於鋅鹽吸收的影響 另補充二篇有關食物對於zinc sulfate吸收影響之文獻摘要。 Effect of foodstuffs on the absorption of zinc sulfate. Clin Pharmacol Ther. 1975 Apr;17(4):469-74. \o Click to search for citations by this author. Pecoud A, \o Click to search for citations by this author. Donzel P, \o Click to search for citations by this author. Schelling JL. Single doses of zinc sulfate were given to healthy young volunteers, either in the fasting state or with various types of meals. Dairy products (milk and cheese) and brown bread decreased zinc absorption, as indicated by a significant drop in peak serum zinc levels. Zinc absorption was decreased when zinc was given in the fasting state with the same amounts of purified phosphate or phytate as those found in foods above. Experiments in vitro have shown that zinc is precipitated by phosphate and phytate at pH values close to that of the intestinal lumen. Coffee also seems to inhibit zinc absorption. Dietary factors influencing zinc absorption J Nutr. 2000 May;130(5S Suppl):1378S-83S. \o Click to search for citations by this author. 　Lonnerdal B. Marginal zinc deficiency and suboptimal zinc status have been recognized in many groups of the population in both less developed and industrialized countries. Although the cause in some cases may be inadequate dietary intake of zinc, inhibitors of zinc absorption are most likely the most common causative factor. P