Chapter 4 Application of Designing Safer Chemicals 4.1 Isosteric Replacement of Carbon with Silicon (用硅对碳进 行等电排置换) in the Design of Safer Chemicals 4.2 Designing Biodegradable Chemicals 4.3 Designing Aquatically Safer Chemicals References 4.1 Isosteric Replacement of Carbon with Silicon in the Design of Safer Chemicals 4.1.1 Silicon is an Isosteric atom of Carbon Common Features of Silicon and Carbon grouped in column 4A of the Periodic Table having many chemical similarities : tetravalent, tetrahedral, and fo
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