第5讲 抗感染免疫.ppt

Figure 1?Activators of the inflammasome. Activators of the inflammasome are divided into two categories: Sterile activators include host- and environment-derived molecules, and pathogen-associated activators include PAMPs derived from bacteria, virus, fungus, and protozoa. Assembly of the NLRs, ASC, and caspase-1 leads to the formation of a penta- or heptamer structure: the inflammasome. Activation of the inflammasome leads to maturation and secretion of IL-1β and IL-18 as well as inflammatory cell death, by either pyroptosis or pyronecrosis. (Abbreviations: ASC, apoptosis-associated speck-lik