英文-两种双嘧达莫缓控释制剂比格犬体内药动学考察资料精.pdfVIP

Pharmacokineticsoftwomodifiedrelease system of in dipyridamoledogs beagle andWei．SanPan+ Zhi—HongZhang，Chang．GuangWang，Guang—MeiSun，NingLi，BoPeng School Pharmaceutical ofPharmacy,ShenyangUniversity,Shenyang110016,China Abstract：AhoveI osmotic release controlled traditionalmatrixsustainedrelease floating pump system(FOP)and tablets(MTl of in characterizedtermsof invitro．invivocorrelation．／n dipyridamole(DIP)were pharmacokinetics，drugrelease，and vivo was athree-crossoverinsix relativetotheconventional studyperformedby study beagledogs tablet(CTl．AHPLCmethodfor thedeterminationofDIPinthe was of fractionwas to absorption thatof加 plasmadeveloped．Cumulativepercent compared vitrocumulativerelease．BothFOPandMT obviousextended vil20 displayed releasecharacteristicin whileFOPshowedabetter extendedreleasebehavior．The ofFOPwas thanthatofMTandazero．orderrelease1inearcorrelationof bioavailabi／ity higher DIPbetweenfractionabsorbedinvivoandfractiondissolvedinvitrowas establishedforFOPwhilenotforMT．Theresultsindicated theexistenceofan in oftheGI window trackofDIP．whichmeantthat couldbeexcellent absorption upperpart floatingsystem for th