慢性阻塞性肺病COPD血清钙磷水平的临床意义初步.doc

PAGE 4 慢性阻塞性肺病（COPD）血清钙磷水平的临床意义初步研究 袁成 程际云 周琳 黄茂 姚欣* 南京医科大学第一附属医院呼吸科 南京 210029 【摘要】 目的 研究COPD患者肺功能与机体钙磷代谢的相关性。方法 提取COPD患者、吸烟者及非吸烟对 照者的肺功能、血清钙磷、是否合并高血压等相关数据进行回顾性分析。结果 与吸烟组和对照相比，COPD组血清钙磷水平降低(P＜0.05和P＜0.01)。是否合并高血压对COPD血清钙磷水平无明显差异(P＞0.05)。在COPD组中肺功能与机体血清钙磷水无明显相关性（P＞0.05）。结论 COPD患者存在钙磷代谢异常，但其血清钙磷水平与肺功能状态未体现明显相关。 【关键词】钙；磷；肺功能；COPD；吸烟 本研究受国家自然科学基金；江苏高校优势学科建设工程资助项目（J；科技部科技重大专项“重大新药创制”(2011ZX09302-003-02)资助 *通讯作者：yaoxin@ Serum calcium and phosphorus levels in COPD YUAN Cheng CHENG Ji-yun ZHOU Lin HUANG Mao YAO Xin* Department of Respiratory Disease，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029 *Corresponding author：YAO Xin. Email: yaoxin@ 【Abstract】 Objective: To investigate the correlation between lung function and serum calcium and phosphorus levels in COPD patients. Methods: Lung function，serum calcium, phosphorus data from COPD group, smoking group and control group were collected for a retrospective analysis. Results: Compared with the smoking and control group，the serum calcium and phosphorus levels were lower in COPD patients (P＜0.05 and P＜0.01，respectively). Hypertension had no effect on serum calcium and phosphorus levels(P＞0.05) in COPD patients. Lung function in COPD group was not significantly related to serum calcium and phosphorus levels(P＞0.05). Conclusion: There is a metabolic abnormality of calcium and phosphorus in COPD patients, although no relationship was been shown between lung function and serum calcium and phosphorus levels. However, further studies are needed. Keywords: Calcium; phosphorus; lung function; COPD; smoking. 慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）是一种以慢性气道炎症和肺气肿为特征的常见病、多发病，其主要临床表现为非可逆性的气流受限而导致肺功能降低，影响患者生活质量 ADDIN EN.CITE EndNoteCiteAuthorZweers/AuthorYear2012/YearRecNum672/RecNumDisplayText[1]/DisplayTextrecordrec-number672/rec-numberforeign-keyskey app=EN db-id=9rx9xt2pm9wt2oewxd7vevdhp2xpfasewz0r672/key/foreign-keysref-type name=Journal Article17/ref-t