联合检测血清肿瘤标志物对大肠癌辅助诊断及预后研究中国肿瘤临床.PDFVIP

2011 年第38 卷第18期 中国肿瘤临床 1169 联合检测血清肿瘤标志物对大肠癌辅助诊断及预后研究 万彩凤 探讨联合检测血清肿瘤标志物在大肠癌诊断和预后判断中的应用。 收集本院自2007 年1 月至2010 年12 摘要 目的： 方法： 月间收治的102例大肠癌患者，以50 例同期健康体检者作为对照，分别检测其血清肿瘤标志物CEA、CA125、CA19-9 和CA724 的 水平。观察肿瘤标志物水平与大肠癌患者临床病理特征的关系及联合检测对诊断敏感度和特异性的影响。 在大肠癌患者 结果： 中，各肿瘤标志物的水平均显著高于对照组，且其水平高低与大肠癌的临床分期和肿瘤的分化程度密切相关。联合检测肿瘤标 志物的水平可显著提高诊断的特异性和敏感度。 联合检测血清肿瘤标志物有助于大肠癌的诊断和判断患者的预后。 结论： 关键词 肿瘤标志物 大肠癌 诊断 预后观察 doi:10.3969/j.issn. 1000-8179.2011.18.029 The Diagnosis and Prognostic Value of the United Detection of Tumor Markers in the Patients with Cancer of Colon. Caifeng WAN Correspondence to: Caifeng WAN, E-mail: wancaifeng@136.com The Department of Inspection, Kanghua Hospital, Haining 314400, China Abstract Objective: To observe the application of the united detection of tumor markers in the diagnosis and prognosis of co- lon cancer. Methods: Up to 102 patients with colon cancer from 2007 to 2010 in kanghua hospital were enrolled and 50 healthy donors were used as the control. The levels of CEA, CA 125, CA19-9, and CA724 were detected whereas their relationship with the clinical stages and the degrees of differentiation of rectal and colorectal carcinoma was analyzed. The effects of the united detection on the sus- ceptibility and specificity were observed. Results: The levels of CEA, CA 125, CA19-9, and CA724 in patients with colon cancer were significantly higher than that in the control group. The levels of the tumor markers were also correlated with the clinical stages and de- grees of differentiation. The united detection of tumor markers co