PSCI的筛查与诊治.ppt

香港采用30分， 对照组的1.5SD(小于等于21分划界分）Wong A, et al. J Neurol Neurosurg Psychiatry 2013;84:499–504 The protocol assesses 5-word recall (5 points), 6-item temporal orientation (6 points), and phonemic fluency (1 point if 10 words that begin with the letter “F” generated in 60 seconds). The range of scores of the 5-Minute Protocol is 0–12, with higher scores indicating better performance. J Int Neuropsychol Soc. 2014 September ; 20(8): 856–867. NINDS-CSN 5-Minute Protocol, raw score Memory (0 – 5 pts) 4.0±1.3 Orientation (0 – 6 pts) 5.76±0.56 Fluency (0 for 11 words; 1 for 11 or more words) 0.51±0.50 Total 10.2±1.7 （1.5SD——7.65） * Subjects were considered cognitively impaired using cut-off points of MMSE as 17/18 for illiterates, 19/20 for individuals with 1 to 6 years of education, and 24/25 for those with 7 or more years ofeducation [22,23]; and the corresponding cut-off points of MoCA were 13/14, 19/20 and 24/25 for illiterates, individuals with 1 to 6 years of education, and those with 7 or more years of education, respectively [24]. * * MoCA是由加拿大Charles LeMoyne医院神经科临床研究中心Nasreddine等参考MMSE制订，于2004年11月确定最终版本 包括视空间与执行功能、命名、记忆、注意、语言、抽象、延迟回忆和定向力8个认知领域12道题，共计30分，完成整个检查约需要10min 可用于快速筛查轻度认知功能损害（MCI） * Two supplemental tests-the Chinese version of MMSE and MoCA, Beijing version (MoCA-BJ) were also evaluated in our study. Subjects were considered cognitively impaired using cut-off points of MMSE as 17/18 for illiterates, 19/20 for individuals with 1 to 6 years of education, and 24/25 for those with 7 or more years ofeducation [22,23]; and the corresponding cut-off points of MoCA were 13/14, 19/20 and 24/25 for illiterates, individuals with 1 to 6 years of education, and those with 7 or more years of education, respectively [24]. * 94例MCI，93例可能的轻度AD患者和90名健康对照进行了MoCA和MMSE的认知功能评估，结果MoCA检出MCI和轻度AD的敏感性分别为90％和100％，而MMSE仅为l8％和78％，同时两者都具有良好的特异性，分别为87％和100％。该试验还证实MoCA的良好信度，平均重测差异小于1分，Cronbaehot系数为0.83。韩国Lee等 在196例包括了轻度AD、MCI和正常对照的老年人中进行了MoCA韩语版、MMSE、临床痴呆评定量表(CDR)和神经心理成套测验，显示M