HLA分子的研究进展教学课件.pptx

HLA分子的研究进展;;HLA (人类白细胞抗原）;;研究对象和方法;供受者基本特征;结果;在6/10相合组HLA-I类相合或A位点相合对OS和RFS的影响;供受者与脐血单倍型分析方法（示例）;脐血单倍型对OS和RFS的影响;讨论;;;;;;Haploidentical HSCT: DSA correlated with primary graft failure and lower survival ;Haploidentical HSCT: C1q and DSA correlated with graft failure;Cord Blood Transplantation: The impact of Anti-antibody on GvHD and OS in chlidren ;;移植前预存HLA抗体是判断HSCT预后的独立危险因素 移植前预存HLA-I类抗体影响HSCT的长期生存率,而HLA-II类抗体与抗体阴性相比无差异 移植前预存低滴度HLA-I类抗体,特别是HLA-A和C抗体影响HSCT的生存率;课题组前期研究结果二;; 第二代测序技术 Next Generation Sequencing;DNA fragment Specific sample/ library preparation;NGS与SSP、SSOP及SBT方法的比较;NG