仓鼠的日常-仓鼠的寿命有多长.docVIP

仓鼠的日常-仓鼠的寿命有多长 “支链氨基酸”延长小白鼠寿命全文　　CellMetabolism 　　Article 　　Branched-ChainAminoAcidSupplementationPromotesSurvivalandSupportsCardiacandSkeletalMuscleMitochondrialBiogenesisinMiddle-AgedMice 　　GiuseppeD’Antona,1,2MaurizioRagni,3AnnalisaCardile,3LauraTedesco,3,4MartaDossena,3,5FlaviaBruttini,1,2FrancescaCaliaro,1,2GiovanniCorsetti,6RobertoBottinelli,1,,3,4AlessandraValerio,3,5andEnzoNisoli3,4,* 　　ofPhysiology,HumanPhysiologyUnitInstituteofMyology 　　PaviaUniversity,Pavia27100,Italy 　　3CenterforStudyandResearchonObesity,DepartmentofPharmacology,ChemotherapyandMedicalToxicology,SchoolofMedicine,MilanUniversity,Milan20169,Italy 　　4IstitutoAuxologicoItaliano,Milan20165,Italy5PharmacologyUnit6HumanAnatomyUnit 　　DepartmentofBiomedicalSciencesandBiotechnologies,BresciaUniversity,Brescia25123,Italy*Correspondence:@/ 　　2Interuniversity1Department 　　SUMMARY 　　Recentevidencepointstoastrongrelationshipbetweeni(BCAAs),theroleoftheseam,weshowthataBCAA-enrichedmixture(BCAAem)n1expressioninprimarycardiacandskeletalmyocytesandincardiacandskeletalmuscle,butnotinadiposetissueandliverofmiddle-agedmice,,thereac-tiveoxygenspecies(ROS)defensesystemgeneswereupregulated,ndrialbiogenesisinmammals. 　　INTRODUCTION 　　Agingisanaturalprocessthataffectsmostbiologicalfunctionsandresultsinreducedresistancetostress,increasedvulnera-bilitytodiseases(includingcardiovasculardisease,cancer,diabetes,sarcopenia,osteoporosis,andkidneydisease),,themalfunctionofmitochondriaandthedecreaseofmitochondrialbiogenesis,togetherwith 　　increasedoxidativedamage,seemtoexertsomeofthemost 　　′pez-deleteriouseffectsontheorganism(Guarente,xx;LoLluchetal.,xx).Avarietyofstrategiesthatalleviateage-relatedde?citsinmitochondrialbiogenesisandactivity,includingcalorierestriction(CR)andmoderatephysicalexercise,-activatedreceptorgcoactivator-1a(PGC-1a,amasterregulatorofmito-chondrialbiogenesisandreactiveoxygenspecies[ROS]defensesystem)andofsirtuin1(SIRT1,amemberofthesirtuinfamilylinkedtolifespanextension,enhancedmitochondrialbiogenesis