垂体促甲状腺激素腺瘤的诊治·临床研究与应用-中国肿瘤临床.PDF

中国肿瘤临床2018年第45卷第10期 ChinJClinOncol2018.Vol.45.No.10 513 临床研究与应用 · · 垂体促甲状腺激素腺瘤的诊治 ① ② ③ 张建宇 刘福增 关健 摘要 目的：分析垂体促甲状腺激素（thyroidstimulatinghormone，TSH）腺瘤的临床特点和诊治经验。方法：总结2006年1月至 2014年2月于中国人民解放军第二五一医院诊治的14例垂体TSH瘤的诊断、治疗过程及预后。结果：14例患者中，2例直接接受 手术治疗，另外12例术前接受药物治疗后，再给予手术治疗。其中10例全切患者的甲状腺功能恢复正常，4例未能全切除的患者 行术后放疗出现垂体功能低下，行激素替代治疗。结论：重视垂体TSH腺瘤的早期诊断，适当进行围手术期处理，选择恰当手术 时机，以期为早期发现并给予正确的治疗提供依据。 关键词 垂体促甲状腺素 垂体瘤 微腺瘤 治疗 doi:10.3969/j.issn.1000-8179.2018.10.316 Experience in the diagnosis and treatment of thyroid- stimulating hormone- secreting pituitary adenoma 1 2 3 Jianyu Zhang , Fuzeng Liu , Jian Guan Correspondence to: Fuzeng Liu; E-mail: 163.com 1Department of Tumor, the 251st Hospital of PLA, Zhangjiakou 075000, China; 2 Department of Neurosurgery, the 251st Hospital of PLA, Zhangjiakou 075000, China; 3 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Abstract Objective: To analyze clinical characteristics and experiences in the treatment of thyroid-stimulating hormone (TSH)-secret- ing pituitary adenoma. Methods: To summarize the diagnosis, treatment and prognosis of 14 cases of pituitary thyrotropin (TSH) tu- mor in the Department of Neurosurgery, 251 Hospital of China Peoples Liberation Army (PLA) from January 2006 to February 2014. Re- sults: Of 14 patients, two received direct surgical treatment and 12 received drug treatment before surgery. Thyroid function fully re- covered in 10 patients who underwent total tumor resection. Four patients, for whom resections failed, were treated with hormone re- placement therapy after radiotherapy. Conclusions: It is important