闪光刺激在癫痫病人脑内电极的生理光驱动及病理光效应研究.pdf

军医进修学院学报 J Chinese PLA Postgrad Med Sch Aug 2012，33（8） 811 闪光刺激在癫痫病人脑内电极的生理光驱动及病理光效应研究 1 2 2 2 2 1 徐　欣 ，Navarro V ，Dinkelacker V ，Dupont S ，Adam C ，凌至培 1 2 解放军总医院 神经外科，北京　100853 ；Pitié-Salpêtrière 医院 癫痫病术前评估单元，法国巴黎 摘要 ：目的 报告 1 例癫痫病人脑内电极对闪光刺激的反应。方法 1 例部分性难治性癫痫病人在术前评估时利用立体定向 技术，在枕 - 颞叶脑组织内不同部位置入电极，病人处于睁眼或闭眼状态，使用 1-40Hz 频率的光源刺激。结果 出现明显 生理性光驱动的电极接触点全部处于枕叶内侧面，靠近距状裂，但不同的电极接触点由于位于距状裂上下及距离其远近不 同，出现生理光驱动的效果不同，未发现病理性光效应。结论 通过癫痫病人脑内电极的置入，特别是在枕叶内侧面置入 脑内电极，可以得到确切的关于视觉系统的生理信息。 关键词 ：闪光刺激 ；癫痫 ；脑内电极 ；生理性光驱动 ；病理性光效应 中图分类号：R 742.1　文献标识码：A　文章编号：1005-1139(2012)08-0811-03　DOI ：10.3969/j.issn.1005-1139.2012.08.005 网络出版时间：2012-04-12 09:17　　 网络出版地址 ：/kcms/detail/11.3275.R0917.001.html Photic stimulation with physiological light driving intracranial electrodes in epilepsy patients and its pathological photo-effect 1 2 2 2 2 1 XU Xin , Navarro V , Dinkelacker V , Dupont S , Adam C , LING Zhi-pei 1Department of Neurosurgery, Chinese PLA General Hospital, Beij ing 100853, China; 2Unité Dépileptologie Dexplorations Pré- chirurgicales, Pitié-Salpêtrière Hospital, Paris, France Corresponding author: LING Zhi-pei. Email: zhipeilxx @163.com Abstract: Objective To report the response of an epilepsy patient to photic stimulation of intracranial electrodes. Methods A patient with refractory epilepsy was assessed with SEEG before operation. Electrodes were implanted into different sites of occipital- temporal lobes. The opened or closed eyes of the patient were stimulated with light source at the frequency of 1-40Hz. Results All the significant contacts of physiological light–driven electrodes, located in the medial occipital lobe, were close to the calcarine fissure. The photo-effect was different at different contacts of intracranial electrodes due to different distances to the calcarin