NSCLC驱动基因检测组织标本替代品的评价.ppt

Accuracy of cfDNA for EGFR mutation Indicating cfDNA had high diagnostic accuracy： Compared with NSCLC tumor tissues, the pooled sensitivity and specificity of cfDNA for the detection of EGFR mutation status were 0.674 (95%CI: 0.517–0.800) and 0.935 (95%CI: 0.888–0.963), respectively; The PLR and NLR of cfDNA were 10.307 (95%CI: 6.167–17.227) and 0.348 (95%CI: 0.226–0.537), respectively; The DOR was 29.582 (95%CI: 4.582–60.012) , SROC with AUC of 0.93 (95% CI: 0.90–0.95) ; Sub-group: sample size, countries, detection methods, and TNM stages were consistent across different sub-