康艾注射液联合化疗治疗晚期胃癌的临床研究.docVIP

康艾注射液联合化疗治疗晚期胃癌的临床研究 吴莉，杨怡 （贵州省人民医院肿瘤科，贵阳550002） 提要：目的 探讨康艾注射液联合化疗在治疗晚期胃癌中的作用。方法 将80例晚期胃癌患随机分为治疗组（化疗加康艾注射液组）和对照组（单纯化疗组）。观察比较两组细胞免疫功能的变化、近期疗效、生活质量改善和毒副反应。结果 治疗组治疗后NK细胞活性，CD4/CD8比值明显高于治疗前，差异有显著性（P0.01），CD3、CD4值升高，差异有显著性（P0.05）。对照组治疗后NK细胞活性、CD3、CD4、CD4/CD8值均较治疗前低，差异有显著性（P0.05）。治疗组与对照组近期疗效有效率分别为45.5%和40.0%，差异无显著性（P0.05）。治疗组在白细胞减少、恶心呕吐、周围神经毒性发生率方面均明显低于对照组，差异有显著性（P0.05）。治疗组在乏力减轻、食欲增加、kamfsky增加高于对照组，差异有显著性（P0.01）。在疼痛减轻、体重增加方面治疗组也高于对照组，差异有显著性（P0.05）。结论：康艾注射液联合化疗治疗晚期胃癌可降低化疗对患者细胞免疫功能的影响及不良反应，改善患者的生活质量。 关键词：胃癌 化疗 康艾注射液 A Clinical Stuy of Treating Advanced Gastric Cancer with the Combination of Kang-ai Injection and Chemotherapy. Wu Li, Yang Yi (Department of Oncology, Guiyang Provinical People’s Hospital, Guyang 550004) Abstract: Objective: to explore the effect of treating advanced gastric cancer with the combination of Kang-ai Injection and chemotherapy. Methods: 80 patients with advanced gastric cancer were randomly divided into treatment group (chemotherapy + Kang-ai Injection) and control group ( chemotherapy only). Observation was conducted on cellular immunization, short-term effect, life quality improvement, and toxic side-effect in both groups. Results: in the treatment group, both NK cellular activity and CD4/CD8 ratio were higher after the treatment and the difference was significant (p0.01); CD3 and CD4 were both increased and the difference was significant (p0.05). In the control group, the NK cellular activity, CD3, CD4, CD4/CD8 ratio were all lower after the treatment and the difference was significant (p0.05). The short-term efficacy rate was 45% in the treatment group and 40% in the control group. The difference was not significant. The treatment group was apprarently lower than the control group in leukopenia, nausea and/vormitting, and peripheral nerve toxicity (p0.05). Compared with the control group, less fatigue, better appetite, and kamotsky increase were observed in the treatment group, and the difference was signficant (p0.01). The treatment g