中山大学肿瘤防治中心.pptVIP

IBM Confidential ? Overexpression of HER2/neu is common in multiple malignancies, including breast, ovarian, lung and prostate cancer, etc. ? Clinical studies have demonstrated that elevated HER2/neu expression correlates with poor prognosis in multiple malignancies ? During the last decade, HER2/neu has been targeted in order to develop novel anticancer drugs Trastuzumab (Herceptin?) Lapatinib (Tykerb) ------ efficacy and long-term use in patients are quite limited due to resistance to these inhibitors or severe side effects ? Anthraquinone deri