分子生物学(武汉大学).pptVIP

Crick is best known for his work in the discovery of the double helix, but since then he has made many other discoveries. After his discovery of the double helix, Crick went to work on finding the relationship between DNA and genetic coding. During this study with Vernon Ingram, they discovered the function of the genetic material in determining the specificity of proteins. In 1957, Crick began work with Sydney Brenner to determine how the sequence of DNA bases would specify the amino acid sequence in proteins. Crick established not only the basic genetic code, but predicted the mechanism for protein synthesis (McMurray, 427) This worked led to many RNA/DNA discoveries and helped in the creation of the DNA/RNA dictionary. In 1960 Crick began to study the structure and possible functions of certain proteins associated with chromosomes called histones. Crick finally left Cambridge Laboratories in 1976 to become Kieckhefer Professor at Salk Institute for Biological Studies in San Diego, California. It was there that Crick began his present project of the study of the brain. Rosalind Elsie Franklin: Pioneer Molecular Biologist From /ScienceWomen/franklin.html (San Diego Supercomputer Center) The Central Dogma (1953-1956) Setting the platform for molecular biology only takes 0.5 year or 3.5 years after the DNA double helical structure is revealed Exciting days of biologists ***** Gene Expression The revised central dogma ---The framework of this course RNA processing Gene regulation 基因组的保持 基因组的表达 The purpose of Molecular Biology of the genes is to provide a firm foundation for understanding how DNA functions as the template for biological complexity. Ch 2 Nucleic Acids convey genetic information Remember: this book is framed the Central Dogma in understanding life, post-genomic era has added more layers of complexity to enrich and elevate the concept of central dogma. Part 2, Maintenance of the Genome, describes the structure of the ge