细胞信息的传递.pptVIP

Chapter 16 section 1 Ⅰ、 Intercellular signaling  substance the pathways of intercellular signaling substances affect the cellular functions Section 2 receptor G proteins in the process of the signal transduction Ⅱ 、acting characteristic of receptor Ⅲ、Regulation of the activity of receptor section 3The pathway of signal transduction （二）the pathway of Ca2+-dependent protein kinase The pathway of Ca2+－phospholipid dependent protein kinase (2) Structure and function of PKC 2. The pathway of Ca2+-CaM-dependent protein kinase (1) constituents： receptor, G protein, PLC, IP3, Ca2+, calmodulin, CaM-kinase 四、The pathway of tyrosine protein kinase （ 五）The pathway of nuclear factor ?Ｂ nuclear factor- ? B (NF- ?B) : Ⅱ、Signal transduction mediated  by intracellular receptor section 4  crosstalking of signal transduction Member of one signal pathway can join to activate or inhibit another signal pathway. Two different signal pathway can together effect on same effectic proteins or same regulatory region of gene to bring into play effection. A kind of signal molecule can effect on several pathways of signal transduction.  section 5 signal transduction and disease summary 信息传递过程中的Ｇ蛋白 Ｇ蛋白的类型 ?亚基 功 能 Gs ?s 激活腺苷酸环化酶 Ｇi ?ｉ 抑制腺苷酸环化酶 Ｇq ?q 激活磷脂酰肌醇特 异性的磷脂酶Ｃ Ｇo* ?o 大脑中主要的Ｇ蛋 白,可调节离子通道 传导素 Ｔa 激 活 视 觉 自身磷酸化（autophosphorylation)： 当配体与单跨膜螺旋受体结合后，催化型受体大多数发生二聚化，二聚体TPK的被激活，彼此可使对方的某些氨基酸残基磷酸化，这一过程称为自身磷酸化。 （一）cAMP-蛋白激酶Ａ途径 1、组 成： 胞外信息分子（主要是胰高血糖素、肾上腺素和促肾上腺皮质激素） 受体，G蛋白，AC，cAMP , PKA 2.c