药物非房室模型分析.pptVIP

Mechanisms of altered elimination Verapamil has been shown to elevate serum digoxin concentrations in patients receiving both drugs concurrently. A study by Pedersen et al (Clin Pharmacol Ther 30:311-316, 1981.) examined this interaction with the following results.: Treatment Digoxin Dig + verapamil CLT 3.28 2.17 CLR 2.18 1.73 CLNR 1.10 0.44 STEADY-STATE VOLUME OF DISTRIBUTION Cf Cbp Cf Cbt VP VT Cf Cbp Cf Cbt VP VT CP = Cf + Cbp CT = Cf + Cbt At steady-state: Substitute: * NONCOMPARTMENTAL ANALYSIS Deficiencies of compartmental analysis: Lack of meaningful physiological basis