胰腺内分泌肿瘤的研究进展.doc

Name of Journal: World Journal of Hepatology? ESPS Manuscript NO: 26210 Manuscript?Type: Review Recent advances in the diagnosis and treatment of primary biliary cholangeitis Huang YQ. Primary biliary cholangeitis Ying-Qiu Huang Ying-Qiu Huang, Department of Gastroenterology, General Hospital of Benxi Steel and Iron; the Fifth Clinical College of China Medical University, Benxi 117000, Liaoning Province, China Author contributions: Ying-Qiu Huang independently?wrote the manuscript. Conflict-of-interest statement: The author declares no conflict of interest. Open-Access: This article is an open-access?article?which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed?in?accordance?with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: /licenses/by-nc/4.0/ Manuscript source: Invited manuscript Correspondence to: Ying-Qiu Huang, Professor of Medicine, Chief Physician, Department of Gastroenterology, General Hospital of Benxi Steel and Iron; the Fifth Clinical College of China Medical University, 29 Renmin Road, Pingshan District, Benxi 117000, Liaoning Province, China. huangyingqiu_bx@126.com Telephone:?+86-24Fax: +86-24Received: March 31, 2016 Peer-review started: April 5, 2016 First decision: June 12, 2016 Revised: July 26, 2016 Accepted: August 27, 2016 Article in press: Published online: Abstract Primary?biliary?cholangeitis (PBC), formerly referred to as primary biliary cirrhosis is an infrequent progressive intrahepatic cholestatic auto-immune illness that can evolve into hepatic fibrosis, hepatic cirrhosis, hepatic failure and even result in hepatocellular carcinoma, characterized by a T-lymphocyte-mediated chronisch non-suppurative destructive