生长激素释放激素激动剂GHRH-A对血管钙化的抑制作用.PDF

生长激素释放激素 激动剂（GHRH-A ） 对血管钙化的抑制作用 余红 浙江大学附属第二医院 OCC, 6/2/2018 血管钙化 心血管疾病危险性 • Aging • Atherothrombotic cardiovascular diseases • Diabetes mellitus • chronic kidney disease VC portends a worse clinical outcome and predicts major adverse cardiovascular events 2017/5/29 Smooth muscle cells are the key players in vascular calcification SM-22 Runx α-SMA Ca/Pi Inflammation ALP Contractile SMCs Apoptosis Osteoblast-like SMCs 血管钙化 Oxidant Stress 收缩型 成骨型 ROS Reactive Oxygen Species play a pivotal role in arterial calcification. 3 3 血管钙化 激素的关系 4 钙化患者外周血中GHRH含量降低 血液 血管 5 Unpublished Growth Hormone Release Hormone (GHRH)促生长激素释放激素 2017/5/29 浙江大学医学院附属第二医院 6 Xia X, Yu H, etc., Stem Cells Int, 2016 GHRH Agonist (MR409) Native GHRH (44 aa): •Tyr—Ala—Asp—Ala—Ile—Phe—Thr—Asn—Ser—Ty r—Arg—Lys—Val—Leu—Gly—Gln—Leu—Ser—Ala—Ar g—Lys—Leu—Leu—Gln—Asp—Ile—Met—Ser—Arg (GHRH 1-29) Agonist of GHRH (29 aa) •N-Me-Tyr—D- Ala—Asp—Ala—Ile—Phe—Thr—Asn—Ser—Tyr—Arg— Orn—Val—Leu—Abu—Gln—Leu—Ser—Ala—Arg—Or n—Leu—Leu—Gln—Asp—Ile—Nle—