遗传密码子和氨基酸若干物理化学特性的相关性研究.docVIP

PAGE PAGE 8 遗传密码子和氨基酸若干物理化学特性的相关性研究*? 马飞1 武耀廷2 许晓风3 ** 1清华大学生物信息学研究所 北京 100084 2清华大学生物科学与技术系，生物化学与分子生物学研究所，北京100084 3南京师范大学生命科学学院 南京 210097 摘要：为了揭示密码子性质与氨基酸性质之间可能存在的内在联系，系统地考察了密码子的分子量、亲水性、碱基堆积力和π电子共振能以及氨基酸的分子量、等电点、相对距离、不可取代性和同义密码子数等特性，并对这些性质间可能存在的相关性进行了分析。结果显示，在密码子、氨基酸以及密码子与氨基酸的多项性质间均存在着显著的正相关或负相关。此外，根据密码子的4种特性对20种蛋白质氨基酸进行了分类，这可能在某种程度上真实地反映了密码子与氨基酸的对应联系。文中还对这些内在相关性的可能意义进行了讨论。 关键词：密码子，氨基酸，相关分析 Correlation analysis of some physical chemistry properties among genetic codons and amino acids* MA Fei1, WU Yao-Ting 2，XU Xiao-Feng3** 1Institute of Bioinformatics, Tsinghua University, Beijing 100084, China 2 Institute of Biochemistry and Molecular Biology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China 3Life Science College Nanjing Normal University Nanjing 210097, China Abstract: The origin and evolution of the genetic code is a most interesting yet challenging problem for understanding life phenomena. To reveal the internal relations of the physical chemistry properties among genetic codons and amino acids, we investigated some important characters of codons comprising molecular weight (MW), water affinity, base force and π energy, and those of amino acids including molecular weight, pI value, relative distance, no replace and synonymous codon number. The correlations in these properties were performed using statistical analysis method. The results indicated that there are close relationships not only between the four properties of genetic codons but also between the five properties of amino acids as well as between codon properties and corresponding amino acids ones. In addition, the 20 kinds of amino acid could be classified into four groups based on four properties of codons, which may reflect the veritably corresponding relationships between codons and amino acids to some extent. Finally, the meaning of the internal relations among genetic codons and amino acids characters was discussed. It is clear that comprehen