Scherer-2011-Lipid profiling of l英文文献资料.pdfVIP

Biochimica et Biophysica Acta 1811 (2011) 918–924 Contents lists available at ScienceDirect Biochimica et Biophysica Acta journal homepage: www. /locate/bbalip Review Lipid profiling of lipoproteins by electrospray ionization tandem ☆ mass spectrometry Max Scherer, Alfred Böttcher, Gerhard Liebisch ⁎ Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany a r t i c l e i n f o a b s t r a c t Article history: Lipoproteins are of fundamental importance for the lipid transport and cardiovascular disease. The function Received 17 January 2011 and metabolism of lipoproteins is intimately linked to the biophysical properties of their surface lipids. Received in revised form 30 May 2011 Although a number of disease associations were found for lipid species in plasma, only a few studies reported Accepted 14 June 2011 lipid profiles of lipoproteins. Here, we provide an overview of techniques for lipoprotein separation, methods Available online 26 June 2011 for lipid species analysis based on electrospray ionization tandem mass spectrometry (ESI-MS/MS) as well as data from recent lipidomic studies on lipoprotein fractions. We also discuss the different analytical strategies Keywords: Lipoprotein separation and how lipid profiling can expand our understanding of the biology and structures of lipoprotein