ACS抗凝与出血风险的再认识(济南)2010.10.pptVIP

ACS患者抗凝与出血风险再认识 山东大学齐鲁医院 陈玉国 2010. 10. 23 出血易感人群及相关因素 ACS患者出血导致不良预后 基于出血的30天死亡事件OASIS 注册、 OASIS-2及CURE研究 (n=34146) ACS患者出血使死亡率升高的机制 血流动力学障碍 交感神经兴奋状态 输血诱发的微循环失调、NO耗竭、免疫作用 炎症反应 停用抗血栓药 * * * * As seen in this nomogram each predictor receives a score based on the range of that predictor. For example, a patient with baseline hematocrit of 29 would receive a score of 9. To test the reliability of the CRUSADE Bleeding Score, we calculated c-statistics for the Bleeding Score in the derivation and validation cohort. Like the multivariate reg