注射用紫杉醇(白蛋白结合型)—ABRAXANE精编PPT课件.pptVIP

MX-1人乳腺癌荷瘤小鼠接受等剂量Abraxane与Taxol（30mg/kg）疗效比较 等毒性剂量Abraxane与Taxol对不同荷瘤裸鼠的疗效比较(每组N = 5， IV qd x 5 days) Lung Prostate Ovarian Desai N, Yao Z, Soon-Shiong P, et al. Evidence of enhanced in vivo efficacy at maximum tolerated dose (MTD) of nanoparticle paclitaxel (ABI-007) and Taxol in 5 human tumor xenografts of varying sensitivity to paclitaxel [abstract]. Proc Am Soc Clin Oncol. 2002;21:116a. Abstract 462. 溶剂对化疗药物的影响 ten Tije, et al. Clin Pharmacokinet 2003;42:665-685; Gelderblom H, et al. Eur J Cancer 2001;37:1590-1598; Verweij J, et al. Ann Oncol 1994;6:495-505; Battafarano DF, et al.