间充质干细胞的免疫调节作用及临床应用.PPTVIP

MSCs secrete cytokines either “spontaneously” or after induction by other cytokines, the most important being IFNγ, TNFα and IL-1β. 间充质干细胞分泌细胞因子，或者是“自发的”，或者是通过其它细胞因子诱导活化而产生的，可诱导间充质干细胞激活的最重要的细胞因子有IFNγ, TNFα 和IL-1β。 四、间充质干细胞免疫调节的可塑性 MSC-mediated immunosuppression requires preliminary activation of the MSCs by immune cells through the secretion of the proin?ammatory cytokine IFNγ, alone or together with TNFα, IL-1α or IL-1β. 间充质干细胞介导的免疫抑制作用需要免疫细胞分泌的促炎因子的激活。 * It should be pointed out that MSCs themselves are objects of cytokine regulation. 应当明确的是间充质干细胞本身也是细胞因子调节的目标。 Clin