热熔挤出技术制备热敏性姜黄素固体分散体的研究_徐艳.pdfVIP

4014 中草药 Chinese Traditional and Herbal Drugs 49 17 2018 9 • 药剂与工艺 • 徐 艳 1, 2，张心怡 1, 2，狄留庆 1, 2，樊文玲 1, 2, 3*# 1. 210023 2. 210023 3. 210023 Eudragit E POEPO X 100 r/min130160 R283.6 A 0253 - 2670(2018)17 - 4014 - 08 DOI: 10.7501/j.issn.0253-2670.2018.17.008 Preparation of thermosensitive curcumin solid dispersions by hot-melt extrusion technique XU Yan1, 2, ZHANG Xin-yi1, 2, DI Liu-qing1, 2, FAN Wen-ling1, 2, 3 1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China 2. Jiangsu Engineering Research Center for Efficient Delivery System of Traditional Chinese Medicine, Nanjing 210023, China 3. Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing 210023, China Abstract: Objective Hot-melt extrusion technique was applied to prepare curcumin solid dispersions, which can improve the solubility and dissolution of curcumin. Methods Using curcumin as a model drug and Eudragit E PO (EPO) as a carrier, the solubility parameter method was used to evaluate the miscibilty between the drug and the carrier. Taking the content, crystallinity, and dissolution of curcumin as evaluation indicators, the single-factor test was used to select the barrel temperature, screw speed, and cooling rate in the hot-melt extrusion process. The preparation process was optimized and compared with the solvent method and the fusion method. By means of differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, saturated solubility measurement and