研究生专业英语教学课件.ppt

GLUT2 lowest affinity for glucose, also transport fructose liver, pancreatic islet cells, retina, stomach overexpression in gastric tumors was not detected in insulinomas or other types of islet cell tumors GLUT3 overexpression in many tunors brain, placenta, testes means poor prognosis highest affinity for glucose and insensitive to insulin GLUT4 cardiac muscle, skeletal muscle, adipose overexpression in gastric and breast cancer GLUT5 kidneys, testes, small intestine, muscle, adipose tissue overexpression in renal cell carcinoma, breast and prostate cancer high affinity for glucose and sensitive to insulin high affinity for fructose GLUT8 testis, adrenal gland, liver, spleen and lung. overexpression in multiple myeloma GLUT12 overexpression in breast cancer heart, small intestine, skeletal muscle Factors regulating expression of GLUTs, HK2, PFK1, PKM2 1. hypoxia 2. oncogene and tumor supressor gene C-myc p53 3. growth factors EGF 4. hormones estrogen hypoxia-inducible factor-1, HIF-1 HIF-1β HIF-1α stable prolyl hydroxylases (PHDs) hydroxylation O2 + transcription of target genes GLUT1 GLUT3 HK2 PDK1 LDHA PKM2 hypoxia SCI: Science Citation Index Institute for Scientific Information 3500 Impact factor 杂志全称 缩写 中文译名 影响因子 CA: a cancer journal for clinicians CA Cancer J Clin 癌 115.84 Nature reviews. Cancer Nat. Rev. Cancer 自然评论：癌症 37.4 The lancet oncology Lancet Oncol. 柳叶刀：肿瘤学 24.69 Cancer cell Cancer cell 癌细胞 23.523 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. 临床肿瘤学杂志 18.428 European urology Eur. Urol. 欧洲泌尿科学 13.938 Journal of the National Cancer Institute J. Natl. Cancer Inst. 国立癌症研究所杂志 12.583 The Journal of experimental medicine J. Exp. Med. 实验医学杂志 12.515 Hepatology (Baltimore, Md.) Hepatology 肝脏病学 11.055 Human reproduction update Hum. Reprod. Update 人类生殖学新资讯 10.165 Seminars in cancer biology Semin. Cancer Biol. 癌生物学文辑 9.33 Cancer research Cancer Res. 癌症研究 9.329 Drug resistance updates : revie