2012年版EASL慢性乙型肝炎管理指南.pptVIP

Lamivudine resistance: switch to tenofovir (add adefovir if tenofovir is not available) (B1). Adefovir resistance: if the patient was NA naive before adefovir, switch to entecavir or tenofovir (B1); entecavir may be preferred in such patients with high viraemia (C2). If the patient had prior lamivudine resistance, switch to tenofovir and add a nucleoside analogue (C1). Telbivudine resistance: switch to or add tenofovir (add adefovir if tenofovir is not available) (C1). Entecavir resistance: switch to or add tenofovir (add adefovir if tenofovir is not available) (C1). Tenofovir resistance: te