NSAIDs相关性溃疡的防治策略分析.pptVIP

* 12. Probability of NSAIDs-associated gastroduodenal damage is related to gastric acidity The pH dependence of NSAID-mediated mucosal damage has also been demonstrated in healthy individuals during a study in which naproxen was given to 37 volunteers for 6 days, either alone or in combination with a gastric antisecretory agent. The study showed that the individuals who benefited from partial inhibition of gastric acid secretion had a significantly lower incidence of gastric pathology (53%) than those whose gastric acidity had remained unchecked (89%; p=0.029). The importance of pH in predict