病理学炎症专业资料.ppt

病理学炎症专业资料;*;*;炎症概述;*;机体参与炎症反应的成分;炎症概述;变质;变 质 alteration;渗 出 exudation;*;增 生 proliferation;炎症概述;History - The Roman physician and medical writer Celsus named the famous 4 cardinal signs of inflammation in Latin as rubor (redness), tumor (swelling), calor (heat), and dolor (pain) in 2 AD. The 5th sign functio laesa (loss of function) was later added by Rudolf Virchow. ;Patient with a Methicillin-resistant Staphylococcus aureus wound infection, and classic signs of inflammation.;炎症局部表现的发生机制;炎症全身反应－发热的发生机制和意义;炎症全身??应－末梢血白细胞计数增高的特点;Immature band form of neutrophil in peripheral blood;2008-9-18;急性炎症 acute inflammation;Cohnheim (German pathologist, 1839-1884), was one of the first pathologists to observe inflammation through the microscope, studying injured blood vessels in transparent membranes from the tongues of frogs and the mesentery. ;血流动力学改变;Interstitial Edema;血管通透性增加;*;2008-9-18;Normal A - HP 30mmHg C - HP 25mmHg V - HP 12mmHg Mean COP 25mmHg;血管通透性增加;白细胞渗出和吞噬作用;白细胞渗出的过程;*;滚动、粘附和游出;;*;To summerize, the events in leukocytes recruitment at an inflammatory site involve: 1) endothelial activation, increasing the expression of selectins and selectin ligands; 2) leukocyte rolling, facilitated by relatively loose selectin binding to carbohydrate ligands; 3) firm adhesion, facilitated by chemokine-induced changes in intergrin affinity for endothelial ligands; and 4) transmigration between endothelial cells utilizing PECAM-1 (CD31) interactions.;白细胞边集和粘附;EM showing transmigration of PMN through vascular wall;白细胞渗出;*;化学趋化作用 chemotaxis;2008-9-18;Neutrophil Crawling on a Glass Slide He’s going this way!;白细胞的种类和特点;白细胞的形态特点;2008-9-18;2008-9-18;2008-9-18;2008-9-18;2008-9-18;白细胞在局部的作用;*;识别和附着 recognition and attachment;识别、附着、吞入;*;杀伤和降解 killing and degradation;活性氧代谢产物的杀伤机制;白细胞在局部的作用;白细胞功能缺陷;炎症介质;炎症介质;细胞释放的炎症介质;Mast Cells Stained with Metachromatic Stain;细胞释放的炎症介质;*;*;细胞释放的炎症介质;细胞释放的炎症介质;*;细胞释放的炎症介质;*;细胞释放的炎症介质;*;细胞释放的炎症介质;体液中的炎症介质;体液中的炎症介质;体液中的炎症介质;体液中的炎症介质;主要炎症介质的作用小结;急性炎症的类型