阿德福韦酯疗效欠佳影响因素分析与优化治疗方案探讨.pdfVIP

中山大学硕士论文 阿德福韦酯疗效欠佳影响因素分析及优化治疗方案探讨 变异株疗效有限。 DNA水平、YMDD变异、对ADV原发 2、“基线HBeAg状态、基线HBV 无应答及初始病毒学应答”可能与ADV疗效欠佳相关。基线HBeAg阳性、基 线HBV DNA水平越高、存在YMDD变异、对ADV原发无应答及未发生初始 病毒学应答的患者越容易发生ADV疗效欠佳。 佳患者三种有效的优化治疗方案。 【关键词】 慢性乙型肝炎阿德福韦酯疗效欠佳优化治疗 中山大学硕士论文 阿德福韦酯疗效欠佳影响因素分析及优化治疗方案探讨 of relevantfactorsand on Analysis investigation preliminary forch B ronic optimaltherapystrategy hepatitispatients q withsnsub 0ntoAdfovirAdfovir res boptimalptimalponse dipivoxil Major： Internalmedicine Name： Li Xiang—yong Advisor：Prof．Yu—Tian Chong ABSTRACT Backgroud ADVhad in of and been usedtheinitialtreatmentCHB widely patientspatients LAM had that half observedaboutof developingresistance．However,clinically,we the adefovir have receiving patients monotherapyasuboptimal’’virologicalresponse wasdefinedasHBVDNA 48 ADV which levels1 afterweeksof 03copies／mL monotherapy． Meterialsandmethod PatientswhomettheinclusioncriteriaandhadreceivedADV for monotherapy v