采用非水电位滴定法测定TRODAT-1盐酸盐含量-中南大学学报.pdf

40 5 () Vol.40 No.5 2009 10 Journal of Central South University (Science and Technology) Oct. 2009 TRODAT-1 ( 214063) TRODAT-1 2 mL 18 mL −(0.02 mol/L) (RSD) 0.29% TRODAT-1 TRODAT-1 O657 A 1672−7207(2009)05−1205−04 Determination of TRODAT-1 hydrochloride by non-aqueous potentiometric titration LI Xiao-min, CHEN Zheng-ping, WANG Song-pei, TANG Jie, LIU Chun-yi (Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China) Abstract: A potentiometric titration method in non-aqueous media was developed for the determination of TRODAT-1 hydrochloride. Optimization of experimental conditions was described. The results show that the procedure is based on the volumetric quantitation of TRODAT-1 hydrochloride in a mixture of 2 mL glacial acetic acid and 18 mL acetic anhydride with 0.02 mol/L perchloric acid-glacial acetic acid, and the end-point of the titration is determined potentiometrically. The method is more environment-friendly than in the presence of acetic mercury. The relative standard deviation (RSD) value is found to be 0.29%, which indicates good precision of the proposed method. Furthermore, this method is simple, rapid, accurate and inexpensive, and it does not require expensive equipment. Therefore, this volumetric method can be incorporated into the routine quality control procedures of TRODAT-1 hydrochloride. Key words: potentiometric titration; non-aqueous; TRODAT-1; acetic anhydride; determination 99mTc-TRODAT-1 (SPECT)