E3泛素连接酶WW想P2对RhoE的调节研究-细胞生物学专业毕业论文.docxVIP

CatalogueABSTRACT Catalogue ABSTRACT ．I 1．INTRoDUCTIoN 一1 1．1 Researching progress of Rnd3／RhoE ．．1 1．2 Researching progress of E3 ligase WWP2 ．13 2．MATERIAI S AND METHoDS 19 2．1 Materials ．．19 2．2 Methods ．23 3．RESULT AND ANAI．YSIS ．43 3．1 WWP2 direcdy interact with RhoE 43 3．2 WWP2 inhibits ubiquitination of RhoE． ． ． ．． ． ．． ．． ． ． ． ． ．．47 3．3 WWP2 regulates actin cytoskeleton 52 3．4 WWP2 enhances cell migration ．53 4．DISCUSSION AND PRoSPECTS 55 4．1 Further research ．． ．．55 4．2 Significance of this study ．57 5．REFERENCE ．．58 ACKNOWLEDGEMENTS ．66 万方数据 摘要RhoE，也被称为Rnd3，是Rho小G蛋白家族中Rnd亚类中的一员。目前