哈佛NIH肿瘤通向个体化用药之路讲义.pptxVIP

哈佛NIH肿瘤通向个体化用药之路;Disease Progression and Personalized Care;Turning the vision into a reality;Assure Access to Samples;Access, Research, Security;Develop aTechnology Platform;The cost decreases exponentially with time;2010: Enabling a New Era in Genome Analysis ;Just Announced: The Life TechnologiesIon Torrent Proton;The USB sequencer ;The Challenge;Make information integration as a central mission;Clinical Data;Conduct research as a vital component;;Identifying modules using ISIS*;Module 2 (gene expression);Module 2Gene set enrichment analysis;Survival and Validation;miRNA expression supports the subtypes;Present data and information to the local community;LGRC Research Portal;LGRC Data Download;LGRC Research Portal;PAGE DETAILSSearch-Facets-Search within results-Keyword prompts-Search historyTable:d results-Sortable columnsActions:-Go to Gene detail page-Add genes to ‘gene set’;Gene Expression Summary;LGRC Research Portal;LGRC Research Portal;PAGE DETAILS- View aggregate statistics-View cohort details-Build cohort sets-Build composite phenotypesActions:-Go to data download for selected cohort -Go to assay detail for selected cohort-Go to cohort manager;LGRC Research Portal;Engage corporate partners;We need to find the best tools;Enable research beyondyour own;John Quackenbush, DirectorMick Correll, Associate Director;The Mission;;Communicate the mission to the community.;The LGRC;Why Patient Involvement is Essential;Genomics is here to stay;johnq@jimmy.harvard.edu