食管癌放化疗面临的挑战和对策讲义.ppt

食管癌放化疗面临的挑战和对策;发病率高 死亡率高 早诊率低 生存率低;;一、放化疗最佳受益人群？;5;Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus;2005.1-2006.12，共153例鳞癌，不能手术 3D-CRT 35%同步铂类化疗 中位剂量64GY（50-74GY） 5Y-OS 26.3% 预后因素：GTV和病灶长度;Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer;CROSS研究;CROSS研究;CROSS研究;CROSS研究;CROSS研究;CROSS研究;Complete resection with no tumor within 1 mm of the resection margins (R0) was achieved in 92% of patients in the chemoradiotherapy–surgery group versus 69% inthe surgery group (P0.001) A pathological complete response was achieved in 47 of 161 pa