抗生素的经验性治疗备课讲稿.pptxVIP

经验性使用抗生素 重症医学科施艳花抗感染治疗的昨天今天与明天抗生素时代感染仍是人类健康的威胁Importance of Adequate and Appropriate Antimicrobial TreatmentOngoing bacterial proliferation and inflammationselection of drug-resistant microorganismsInadequate antimicrobial treatmentAdequate antimicrobial treatmentIncreasedMortalityDecreasedEffect of Early Administration of Antibiotics on OutcomesVariable总计4 h内给抗生素4h 后给抗生素校正的ORp Value30-天死亡率12.0 11.6 12.7 0.85 .005住院死亡率7.0 6.8 7.4 0.85 .03住院时间5天 的百分率43.3 42.1 45.1 0.90 .00330天再入院率13.4 13.1 13.9 0.95 .34Houck PM et al. Arch Intern Med 2004; 164:637-44早期有效的抗生素治疗: 6h黄金时间 脓毒