序列相似性搜索工具.pptVIP

* * * * * * * * * * * * * * * * * Some properties of the equation E = Kmn e-lS The value of E decreases exponentially with increasing S (higher S values correspond to better alignments). Very high scores correspond to very low E values. The E value for aligning a pair of random sequences must be negative! Otherwise, long random alignments would acquire great scores For E=1, one match with a similar score is expected to occur by chance. For a very much larger or smaller database, you would expect E to vary accordingly From raw scores to bit scores There are two kinds of scores