临床耐药和剖析.ppt

* * * * * * * * * Legionella, which comprises more than 40 species, including pneumophila, is widespread in water and, also, soil. The organism lives and grows in amebas.1,2 Water temperatures from 32°C to 45°C encourage growth of the pathogen.1 Legionella infection is spread by water—not person to person, as are the other two main AP pathogens.1 The Legionella organism has a cell wall and is a gram-negative bacillus.2,3 In the human host, Legionella is an intracellular organism: it lives in macrophages.1,2 According to a meta-analysis, the mortality rate due to Legionella spp CAP was 14.7%