肿瘤分子生物学5 肿瘤免疫学若干进展 刘永忠.ppt

肿瘤分子生物学5 肿瘤免疫学若干进展 刘永忠.ppt

DNA damaging agents or HDACi activated NKG2D- mediated cytotoxic activity * Hallmarks of senescent cells Four faces of cellular senescence : JCB 2011- vol. 192 no. 4 547-556 Cell senescence: friend or foe in tumor progression? Cell senescence and innate immune response Nature 2007,445,656 * Irreversible inhibition of tumor growth mediated by P53 is not related to apoptosis * p53 reactivation induces cellular senescence * Clearance of liver tumors by an innate immune response * * Nature 479,547–551; 2011 * Adaptive immunity is critical for senescence-related immune surveillance *

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