astrocyte(星形胶质细胞)教学教材.pptVIP

Astrocyte Reactivity to Unconjugated Bilirubin Requires TNF-α and IL-1β Receptor Signaling Pathways;1 We have reported that tumor necrosis factor (TNF)-α and interleukin (IL)-1β are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB). The effects of these cytokines are mediated by cell surface receptors through a nuclear factor (NF)-κB-dependent pathway that we have showed to be activated by UCB. ;2 Exposure of astrocytes to UCB increased the expression of both TNF- α receptor TNFR1 and IL-1 β receptor IL-1R1, but not TNFR2, as well as their