肥胖儿童血清C反应蛋白与胰岛素抵抗指数关系的研究.doc

肥胖儿童血清C反应蛋白与胰岛素抵抗指数关系的研究 王姝彦 （广东省深圳市第六人民医院 深圳518000） 摘要：目的：分析并探讨肥胖儿童血清C反应蛋白（CRP）与代谢综合征的相关性。方法：选取2013年1月~2014年10月在我院检查的单纯性肥胖儿童50例为观察组，选取同期体检健康儿童50例为对照组；检测患者血清CRP、血压、总胆固醇、甘油三酯、空腹血糖、胰岛素水平，计算BMI，评估胰岛素抵抗指数，并采用Spearman方法分析CRP与上述各项指标的关系。结果：观察组CRP为（1.82±0.85） mg/L，对照组CRP为（0.78±0.21） mg/L。观察组血清CRP明显高于对照组，经统计学检验，差异有统计学意义，P＜0.05；观察组BMI、收缩压、胰岛素、TC、TG、HOMA-IR等各项指标也显著高于对照组，经统计学检验，差异有统计学意义，P＜0.05；血清CRP水平与BMI、收缩压、胰岛素、TG和HOMA-IR均呈正相关。结论：肥胖儿童血清CRP明显高于正常儿童，且与代谢综合征关系密切，临床上要注意儿童肥胖情况，及时的采取相关对策。 关键词：肥胖儿童；血清C反应蛋白；代谢综合征；相关性 Study on the Relativity Between Serum C Reactive Protein and Insulin Resistance Index in Obese Children WANG Shu-yan (The Sixth People’s Hospital of Shenzhen City, Guangdong518000) Abstract: Objective: To analyze and discuss relativity between serum C reactive protein (CRP) and metabolic syndrome in obese children. Methods: From January 2013 to October 2013, chose 50 simple obese children examined in our hospital as observation group, and 50 healthy children were selected as the control group in the same period. Detected the serum CRP, blood pressure, total cholesterol, triglyceride, fasting blood glucose and insulin levels, calculated body mass index (BMI), assessed insulin resistance index, and used the Spearman method to study the relationship between CRP and the indexes mentioned above. Results: The CRP of the observation group (1.82±0.85) mg/L, was significantly higher than the CRP of the control group (0.78±0.21) mg/L, the difference was statistically significant, P0.05. Serum CRP levels were positively correlated with BMI, systolic blood pressure, insulin, TG and HOMA-IR. Conclusion: The serum CRP of obese children was significantly higher than that of normal children, and was closely related to metabolic syndrome. In clinic, we should pay more attention to children’s obesity, and take the relevant measures in time. Key words: Obese children; Serum C reactive protein; Metabolic syndrome; Relativity 中图分类号：R589.2 文献标识码：B 通常来说，C反应蛋白（CRP）是一种非特异性炎性介质，尤