长效CCB的药理与临床解析资料讲解.pptVIP

Blood pressure falls during sleep and rises rapidly just before the time of awakening and arising (Millar-Craig et al, 1978; Mancia et al, 1983). Millar-Craig M, Bishop CN, Raftery EB. Circadian variation of blood pressure. Lancet 1978; I: 795-797. Mancia G, Ferrari A, Gregorini L et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res 1983; 53: 96-104. 人体的血压在清晨醒后数小时迅速升至峰值，多项研究显示，血压的这种晨峰现象致使心血管事件如心肌缺血、心肌梗死、心源性猝死、脑血管事件如脑血栓、脑出血等好发于清晨，即所谓的“清晨危险”。 Elliott WJ. Et al. Cyclic and circadian variations in cardiovascular events. Am J hypertens