缺血再灌注以病例为引导.pptVIP

１ 缩短缺血时间，尽早恢复血流 ２ 低压、低温、低pH、低钠、 低钙液灌流 ３清除活性氧 ４钙拮抗剂的使用 ５抗白细胞疗法 ６补充能量及促进能量生成 7启动细胞内源性保护机制 防治原则 * 缺血预适应是指组织器官经反复短暂缺血后，会明显增强对随后较长时间缺血及再灌注损伤的抵抗力的现象。 * Murry et al. Circulation 1986:74: 1124 Four cycles of 5 min of ischemia with intermittent reperfusion were shown to limit infarct size by 75% * 缺血后适应是指组织器官在缺血后,再灌注前，经反复短暂的再灌注处理，会减轻再灌注损伤。 * ＴＨＥ　ＥＮＤ 谢　谢 * Superoxide dismutase (SOD) is one of the primary antioxidant enzymes. The first SOD was discovered by J. McCord and I. Fridovich in 1969. (McCord, Fridovich, JBC 244:6049, 1969) Three members of SOD family have been ide