LncRNADisease一个长链费编码RNA疾病相关数据库.pptVIP

六.未来发展 LncRNADisease数据库会每两个月更新一次实验支持的lncRNA-疾病关联条目数据 不久的将来，研究人员会开发和整合更多的方法和工具来预测新的lncRNA-关联疾病到LncRNADisease数据库中 七.讨论和结论 在疾病的诊断，治疗，预后方面，LncRNA正在成为很有潜力的分子靶标。 LncRNADisease数据库的建立一定会为非编码RNA的研究提供很大帮助！ 本数据库目前的缺陷是： （1）目前实验支持的数据很有限。 解决:随着研究的火热和深入，越来越多的数据会被发表，并整合到这个数据库中 （2）文献报道并证实的疾病相关非编码RNA少之又少。 解决：本数据库会开发并整合更多的生物信息学工具，用以预测疾病关联非编码RNA. 八.资金赞助 National Basic Research program of China[2012CB517500]; National Natural Science Foundation of China and. Funding for open access charge: National Basic Research program of China [2012CB517500]. 九.引用 1. Bertone,P., Stolc,V., Royce,T.E., Rozowsky,J.S., Urban,A.E., Zhu,X., Rinn,J.L., Tongprasit,W., Samanta,M., Weissman,S. Figure 2. Significance of lncRNAs sharing a common disease with their neighbor genes/miRNAs. Blue triangles indicate the distributions of numbers of lncRNAs associated with the same disease as their neighbor genes/miRNAs in random cases. The red arrow indicates the real number of lncRNAs associated with the same disease as their neighbor genes/miRNAs. Nucleic Acids Research, 2013, Vol. 41, Database issue D985 Downloaded from / at Harbin Medical Uniersity on April 28, 2014 et al. (2004) Global identification of human transcribed sequences with genome tiling arrays. Science, 306, 2242–2246. 2. Kapranov,P., Cheng,J., Dike,S., Nix,D.A., Duttagupta,R., Willingham,A.T., Stadler,P.F., Hertel,J., Hackermuller,J., Hofacker,I.L. et al. (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science, 316, 1484–1488. 3. Mercer,T.R., Dinger,M.E., Sunkin,S.M., Mehler,M.F. and Mattick,J.S. (2008) Specific expression of long noncoding RNAs in the mouse brain. Proc. Natl Acad. Sci. USA, 105, 716–721. 4. Pauli,A., Valen,E., Lin,M.F., Garber,M., Vastenhouw,N.L., Levin,J.Z., Fan,L., Sandelin,A., Rinn,J.L., Regev,A. et al. (2012) Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Res., 22, 577–591. 5. Ponti