肺水腫におけるニトログリセリン舌下錠の臨床応用.pdfVIP

原 著 動物 の循環器 第31巻1号34-42(1998) 肺 水 腫 にお け るニ トロ グ リセ リン舌 下錠 の 臨床 応 用 千村 収一 千村 どうぶつ病院 〒482-0042岩倉市中本町南加路桶20-13 (受理1998年7月14日) Chinical Application of the Nitroglycerin Sublingual Tablet to the Plumonary Edema Syuichi CHIMURA Chimura Animal Hospital, 20-13 Minamikarooke Nakahonmachi Iwakura-City Aichi 482-1142. Japan Abstract. Pulmonary edema is often encountered as an acute symptom of left insufficiency in mitral regurgitation. Diuretics or vasodilator is generally administered to improve pulmonary congestion. Among the nitroglycerin formations, the rapid acting sublingual tablets were selected in this study. A new administration route of sublingual tablets were devised into preputial cavity in male and into vagina in female, Preclinically this administration was performed in clinically healthy dogs. The cardio-vascular behavior after this preclinical administrations to the dogs were almost same of those after sublingual administration to human. We considered that this administration was clinically applicable. Relatively mild cases of pulmonary edema with clinical symptoms, were initially treated with intra-preputial or intra vaginal administration of nitroglycerin sublingual tablets. Remarkable clinical improvement was recognized in these cases. Key words : intra - preputial or intra - vaginal administration, nitroglycerin sublingual tablet, pulmonary edema Adv. Anim. Cardiol. 31(1) : 34-42, 1998