催化不对称Michael加成反应的新进展.pdfVIP

2002 22 Vol.22, 2002 3 , 164 ～ 173 Chinese Journal of Organic Chemistry No.3, 164～ 173 ·· Michael 杜大明 　　花文廷 (　　 100871) 　Michael , , Le is , . 　Michael , , , Recent Progress in Catalytic Asymmetric Michael Additions DU, Da-Ming 　　HUA, Wen-Ting (Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100 71 ) Abstract　Ne methods for catalytic asymmetric Michael addition are summarized including the chiral metallic complex catalyzed reactions, chiral Le is acid complex-promoted asymmetric addition, chiral cro n ether catalyzed reaction and other catalytic reactions. Keywords　Michael addition, asymmetric synthesis, catalytic reaction, enantioselective 　　α,β- 、. (Michael )— 1.1　Michael . β- sp2 Michael 3 sp , Shibasaki [4, 5] [4] .Michael .Shibasaki 1995 La(O-i- , Pr), (R )-BINOL (3 mol)NaOBu-t (3 mol) 3 [1, 2] . --(LSB), Michael —. Michael , 1 92%ee ( 62%～98%), 2 77%ee (93%).LSB 1　Michael LaNa3C60H36O6 ·6THF ·H2O, LSB , , Le is . Michael — “” [ 1～3] .Shibasaki . 、、 Shibasaki, (R )-BINOL E-mail:dudm @pku.edu.cn;Fax:010 Received January 31, 2001;revised May 10, 2001;accepted June 22, 2001. No.3 :Michael